Protein Details: Transient receptor potential cation channel subfamily M member 4
Protein ID
ICDB_Pro_1315
Protein Name
Transient receptor potential cation channel subfamily M member 4
Gene Name
TRPM4; LTRPC4
Organism
Homo sapiens (Human)
Length
1214 amino acids
AlphaFoldDB
AF-Q8TD43-F1-model_v4.pdb
Function
Sequence
Ligand Binding
Binding Site
171;421;448;828;831;865;868
Disease
Progressive Familial Heart Block;Type Ib and Erythrokeratodermia Variabilis Et Progressiva
Location
Widely expressed with a high expression in intestine and prostate. In brain; it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Prominently expressed in Purkinje fibers. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes. .
DOI ID
10.1073/pnas.191360198; 10.1016/s0092-8674(02)00719-5; 10.1016/s0960-9822(03)00431-7; 10.1074/jbc.m305127200; 10.1038/ng1285; 10.1101/gr.2596504; 10.1161/01.res.0000147311.54833.03; 10.1113/jphysiol.2004.063974; 10.1113/jphysiol.2004.070839; 10.1007/s00424-003-1221-x; 10.1126/science.1098845; 10.1074/jbc.m411089200; 10.1074/jbc.m501686200; 10.1074/jbc.m506965200; 10.1016/j.ceca.2006.04.032; 10.1038/sj.emboj.7600963; 10.1080/10799890600637506; 10.1124/mol.105.021154; 10.1016/j.bbrc.2009.11.142; 10.1002/jcp.22310; 10.4049/jimmunol.1000880; 10.1038/nature24674; 10.1126/science.aar4510; 10.1172/jci38292; 10.1161/circgenetics.109.930867; 10.1002/humu.21599; 10.1016/j.jid.2018.10.044
RefSeq
NP_001182156.1 [Q8TD43-3]; NP_001308212.1 [Q8TD43-2]; NP_060106.2 [Q8TD43-1]